Deciding to CAlL it quits is a relatively simple judgment early on in a career. If you find the prospect of going to work on Monday morning more depressing than a Lars von Trier film, it is time to leave. If you have nothing left to learn in your current organisation, you should probably grab more stimulating opportunities elsewhere. But knowing when to quit is less easy when you are in a role that already confers lots of status, novelty and purpose. And moving on is particularly difficult when it might be the last big job you have.
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