Studies Suggest People Who Had Covid-19 Should Get Single Vaccine Dose

The Four Percent


Nearly 30 million people in the United States — and probably many others whose illnesses were never diagnosed — have been infected with the coronavirus so far. Should these people still be vaccinated?

Two new studies answer that question with an emphatic yes.

In fact, the research suggests that for these people just one dose of the vaccine is enough to turbocharge their antibodies and destroy the coronavirus — and even some more infectious variants.

The results of these new studies are consistent with the findings of two others published over the past few weeks. Taken together, the research suggests that people who have had Covid-19 should be immunized — but a single dose of the vaccine may be enough.

“I think it’s a really strong rationale for why people who were previously infected with Covid should be getting the vaccine,” said Jennifer Gommerman, an immunologist at the University of Toronto who was not involved in the new research.

A person’s immune response to a natural infection is highly variable. Most people make copious amounts of antibodies that persist for many months. But some people who had mild symptoms or no symptoms of Covid-19 produce few antibodies, which quickly fall to undetectable levels.

The vaccines “even the playing field,” Dr. Gommerman said, so that anyone who has recovered from Covid-19 produces enough antibodies to protect against the virus.

The latest study, which has not yet been published in a scientific journal, analyzed blood samples from people who have had Covid-19. The findings suggested that their immune systems would have trouble fending off B.1.351, the coronavirus variant first identified in South Africa.

But one shot of either the Pfizer-BioNTech or Moderna vaccine significantly changed the picture: It amplified the amount of antibodies in their blood by a thousandfold — “a massive, massive boost,” said Andrew T. McGuire, an immunologist at the Fred Hutchinson Cancer Research Center in Seattle, who led the study.

Flush with antibodies, samples from all of the participants could neutralize not only B.1.351, but also the coronavirus that caused the SARS epidemic in 2003.

In fact, the antibodies seemed to perform better than those in people who had not had Covid and had received two doses of a vaccine. Multiple studies have suggested that the Pfizer-BioNTech and Moderna vaccines are about five times less effective against the variant.

He and other researchers are trying to persuade scientists at the Centers for Disease Control and Prevention to recommend only one dose for those who have recovered from Covid-19.



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